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Michaela Gruber

Physician-Scientist (Guest)

Michaela has focused her research on chronic lymphocytic leukemia (CLL), a clinically heterogeneous malignancy which can remain asymptomatic for a long time while other cases progress rapidly. The high frequency of CLL and availability of highly pure tumor samples provide opportunities for genetic and epigenetic studies which are unique across cancers. By learning what drives CLL heterogeneity we can thus find insights that aid to understand not only CLL but cancer in general. Currently she is most interested in the interaction of epigenetics with somatic genetic evolution to understand cancer initiation and early development. Thus, she is thrilled by the opportunity to bring together unique CLL sample collections from the Vienna General Hospital with powerful sequencing technologies and bioinformatic pipelines established at Christoph Bock’s lab. In addition, she has previously developed experimental (in vitro and in vivo) CLL and B-cell models that enable her to pursue a variety of functional studies.

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