Publications
This list includes only the lab’s main publications. For a more complete overview with co-authored
publications and citation data, please see Christoph Bock’s Google Scholar profile.
​
* corresponding author; # shared first / shared last author
![GPT-4 as a biomedical simulator](https://static.wixstatic.com/media/52c921_661f5e005bbc4bcf9be70d5d9c1e7124~mv2.jpg/v1/fill/w_185,h_72,al_c,q_80,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_661f5e005bbc4bcf9be70d5d9c1e7124~mv2.jpg)
GPT-4 as a biomedical simulator
Schaefer M, Reichl S#, ter Horst R#, Nicolas AM, Krausgruber T, Piras F, Stepper P, Bock C*, Samwald M*
Computers in Biology and Medicine  178, 108796 (2024). DOI: 10.1016/j.compbiomed.2024.108796
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Press release
![JAK-STAT signaling maintains homeostasis in T cells and macrophages](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41590-024-01804-1/MediaObjects/41590_2024_1804_Fig1_HTML.png?as=webp)
JAK-STAT signaling maintains homeostasis in T cells and macrophages
Fortelny N, Farlik M#*, Fife V, Gorki AD, Lassnig C, Maurer B, Meissl K, Dolezal M, Boccuni L, Ravi Sundar Jose Geetha A, Akagha MJ, Karjalainen A, Shoebridge S, Farhat A, Mann U, Jain R, Tikoo S, Zila N, Esser-Skala W, Krausgruber T, Sitnik K, Penz T, Hladik A, Suske T, Zahalka S, Senekowitsch M, Barreca D, Halbritter F, Macho-Maschler S, Weninger W, Neubauer HA, Moriggl R, Knapp S, Sexl V, Strobl B, Decker T, Müller M, Bock C*
Nature Immunology  25 (2024). DOI: 10.1038/s41590-024-01804-1
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
![Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity](https://www.cell.com/cms/attachment/14f91932-d7a1-477e-b6fc-135c5d01da1f/fx1.jpg)
Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity
Moorlag SJCFM, Folkman L#, ter Horst R#, Krausgruber T#, Barreca D, Schuster LC, Fife V, Matzaraki V, Li W, Reichl S, Mourits VP, Koeken VACM, de Bree CJ, Dijkstra H, Lemmers H, van Cranenbroek B, van Rijssen E, Koenen HJP, Jossten I, Xu CJ, Li Y, Joosten LAB, van Crevel R, Netea M*, Bock C*
Immunity  57/1, 171-187 (2024). DOI: 10.1016/j.immuni.2023.12.005
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
![Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation](https://medical-epigenomics.org/papers/krausgruber2023/img/Top_panel.png)
Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation
Krausgruber T, Redl A#, Barreca D#, Doberer K, Romanovskaia D, Dobnikar L, Guarini M, Unterluggauer L, Kleissl L, Atzmüller D, Mayerhofer C, Kopf A, Saluzzo S, Lim CX, Rexie P, Weichhart T, Bock C*, Stary G*
Immunity  56, 289-306 (2023). DOI: 10.1016/j.immuni.2023.01.014
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
![Comparative analysis of genome-scale, base-resolution DNA methylation profiles across 580 animal species](https://medical-epigenomics.org/papers/DNAmeth500species/img/overview.png)
Comparative analysis of genome-scale, base-resolution DNA methylation profiles across 580 animal species
Klughammer J, Romanovskaia D#, Nemc A, Posautz A, Seid C, Linda, Schuster, Keinath M, Ramos JSL, Kosak L, Evankow A, Prinz D, Kirchberger S, Datlinger P, Fortelny N, Schmidl C, Farlik M, Kaja, Skjærven, Bergthaler A, Liedvogel M, Thaller D, Burger PA, Hermann0 M, Distel M, Distel DL, Kübber-Heiss A, Bock C*
Nature Communications  14, 232 (2023). DOI: 10.1038/s41467-022-34828-y
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
![LIQUORICE: detection of epigenetic signatures in liquid biopsies based on whole-genome sequencing data](https://static.wixstatic.com/media/52c921_ef5d85c9359341abb5e6484317c870a0~mv2.jpg/v1/fill/w_185,h_48,al_c,q_80,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_ef5d85c9359341abb5e6484317c870a0~mv2.jpg)
LIQUORICE: detection of epigenetic signatures in liquid biopsies based on whole-genome sequencing data
Peneder P, Bock C, Tomazou EM*
Bioinformatics Advances  2 (2022). DOI: 10.1093/bioadv/vbac017
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Press release
![High-content CRISPR screening.](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs43586-021-00093-4/MediaObjects/43586_2021_93_Fig1_HTML.png?as=webp)
High-content CRISPR screening.
Bock C*, Datlinger P, Chardon F, Coelho MA, Dong MB, Lawson KA, Lu T, Maroc L, Norman TM, Song B, Stanley G, Chen S, Garnett M, Li W, Moffat J, Qi LS, Shapiro RS, Shendure J, Weissman JS, Zhuang X
Nature Reviews Methods Primers   2, 8 (2022). DOI: 10.1038/s43586-021-00093-4
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Project website
Press release
![Ultra-high-throughput single-cell RNA sequencing and perturbation screening with combinatorial fluidic indexing](https://static.wixstatic.com/media/52c921_9ff0c2c1e5224317b7b7819c06871621~mv2.png/v1/fill/w_185,h_98,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_9ff0c2c1e5224317b7b7819c06871621~mv2.png)
Ultra-high-throughput single-cell RNA sequencing and perturbation screening with combinatorial fluidic indexing
Datlinger P, Rendeiro AF, Boenke T, Senekowitsch M, Krausgruber T, Barreca D, Bock C
Nature Methods  18, 635-642 (2021). DOI: 10.1038/s41592-021-01153-z
Donwload PDF
![Open access logo](https://static.wixstatic.com/media/52c921_87f94e7a576e45e6a642ae78dc3c88f6~mv2.png/v1/fill/w_97,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/open_access.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
![Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden](https://static.wixstatic.com/media/52c921_b737a20689e04219b244f43e868cd436~mv2.png/v1/fill/w_154,h_111,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_b737a20689e04219b244f43e868cd436~mv2.png)
Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden
Peneder P, Stutz AM, Surdez D, Krumbholz M, Semper S, Chicard M, Sheffield NC, Pierron G, Lapouble E, Totzl M, Erguner B, Barreca D, Rendeiro AF, Agaimy A, Boztug H, Engstler G, Dworzak M, Bernkopf M, Taschner-Mandl S, Ambros IM, Myklebost O, Marec-Berard P, Burchill SA, Brennan B, Strauss SJ, Whelan J, Schleiermacher G, Schaefer C, Dirksen U, Hutter C, Boye K, Ambros PF, Delattre O, Metzler M, Bock C, Tomazou EM
Nature Communications  12, 3230 (2021). DOI: 10.1038/s41467-021-23445-w
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
![The Organoid Cell Atlas](https://static.wixstatic.com/media/52c921_5a45cc2be3854b7f8b4921f9b2ccfed0~mv2.png/v1/fill/w_114,h_111,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_5a45cc2be3854b7f8b4921f9b2ccfed0~mv2.png)
The Organoid Cell Atlas
Bock C, Boutros M, Camp JG, Clarke L, Clevers H, Knoblich JA, Liberali P, Regev A, Rios AC, Stegle O, Stunnenberg HG, Teichmann SA, Treutlein B, Vries RGJ, the Human Cell Atlas ‘Biological Network’ Organoids
Nature Biotechnology  39, 13-17 (2021). DOI: 10.1038/s41587-020-00762-x
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Press release
![Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2](https://static.wixstatic.com/media/52c921_5fee51ca826e4f3ba6c66682e3452dec~mv2.jpg/v1/fill/w_125,h_111,al_c,q_80,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_5fee51ca826e4f3ba6c66682e3452dec~mv2.jpg)
Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2
Popa A, Genger JW, Nicholson MD, Penz T, Schmid D, Aberle SW, Agerer B, Lercher A, Endler L, Colaço H, Smyth M, Schuster M, Grau ML, MartÃnez-Jiménez F, Pich O, Borena W, Pawelka E, Keszei Z, Senekowitsch M, Laine J, Aberle JH, Redlberger-Fritz M, Karolyi M, Zoufaly A, Maritschnik S, Borkovec M, Hufnagl P, Nairz M, Weiss G, Wolfinger MT, von Laer D, Superti-Furga G, Lopez-Bigas N, Puchhammer-Stöckl E, Allerberger F, Michor F, Bock C, Bergthaler A
Science Translational Medicine  12, eabe2555 (2020). DOI: 10.1126/scitranslmed.abe2555
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
![Knowledge-primed neural networks enable biologically interpretable deep learning on single-cell sequencing data](https://static.wixstatic.com/media/52c921_39ccfcbe98854742ae41580f2c342fb5~mv2.png/v1/fill/w_184,h_111,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_39ccfcbe98854742ae41580f2c342fb5~mv2.png)
Knowledge-primed neural networks enable biologically interpretable deep learning on single-cell sequencing data
Fortelny N, Bock C
Genome Biology  21, 190 (2020). DOI: 10.1186/s13059-020-02100-5
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
![Structural cells are key regulators of organ-specific immune response](https://static.wixstatic.com/media/52c921_3ee8c78d12b744bfabed40890d7041d3~mv2.png/v1/fill/w_144,h_111,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_3ee8c78d12b744bfabed40890d7041d3~mv2.png)
Structural cells are key regulators of organ-specific immune response
Krausgruber T*, Fortelny N*, Fife-Gernedl V, Senekowitsch M, Schuster LC, Nemc A, Schmidl C, Rendeiro AF, Lercher A, Bergthaler A, Bock C
Nature  583, 296-302 (2020). DOI: 10.1038/s41586-020-2424-4
![Open access logo](https://static.wixstatic.com/media/52c921_87f94e7a576e45e6a642ae78dc3c88f6~mv2.png/v1/fill/w_97,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/open_access.png)
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
![Single-cell RNA-seq with spike-in cells enables accurate quantification of cell-specific drug effects in pancreatic islets](https://static.wixstatic.com/media/52c921_0571cd69243447d4b0bed1df951779c2~mv2.png/v1/fill/w_111,h_111,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_0571cd69243447d4b0bed1df951779c2~mv2.png)
Single-cell RNA-seq with spike-in cells enables accurate quantification of cell-specific drug effects in pancreatic islets
Marquina-Sanchez B*, Fortelny N*, Farlik M*, Vieira A, Collombat P, Bock C*, Kubicek S*
Genome Biology  21, 106 (2020). DOI: 10.1186/s13059-020-02006-2
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
![Chromatin mapping and single-cell immune profiling defines the temporal dynamics of ibrutinib drug response in chronic lymphocytic leukemia](https://static.wixstatic.com/media/52c921_05a047d8f5034ca3bc42f915ae2f25f5~mv2.png/v1/fill/w_88,h_111,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_05a047d8f5034ca3bc42f915ae2f25f5~mv2.png)
Chromatin mapping and single-cell immune profiling defines the temporal dynamics of ibrutinib drug response in chronic lymphocytic leukemia
Rendeiro AF*, Krausgruber T*, Fortelny N, Zhao F, Penz T, Farlik M, Schuster LC, Kuchler A, Tasnády S, Réti M, Zoltán M, Alpar D*, Bödör C*, Schmidl C*, Bock C*
Nature Communications  11, 577 (2020). DOI: 10.1038/s41467-019-14081-6
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
![Epigenomics and single-cell sequencing define a developmental hierarchy in Langerhans cell histiocytosis](https://static.wixstatic.com/media/52c921_4c9467871a814d91bf944914c0f02bb4~mv2.png/v1/fill/w_185,h_83,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_4c9467871a814d91bf944914c0f02bb4~mv2.png)
Epigenomics and single-cell sequencing define a developmental hierarchy in Langerhans cell histiocytosis
Halbritter F*, Farlik M*, Schwentner R, Jug G, Fortelny N, Schnöller T, Pisa H, Schuster LC, Reinprecht A, Czech T, Gojo J, Holter W, Minkov M, Bauer WM, Simonitsch-Klupp I, Bock C*, Hutter C*
Cancer Discovery  9, 1406-1421 (2019). DOI: 10.1158/2159-8290.CD-19-0138
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
![RnBeads 2.0: comprehensive analysis of DNA methylation data](https://static.wixstatic.com/media/52c921_3cd0ca44115c45258e6d409233933428~mv2.png/v1/fill/w_185,h_71,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_3cd0ca44115c45258e6d409233933428~mv2.png)
RnBeads 2.0: comprehensive analysis of DNA methylation data
Müller F*, Scherer M*, Assenov Y*, Lutsik P*, Walter J, Lengauer T, Bock C
Genome Biology  20, 55 (2019). DOI: 10.1186/s13059-019-1664-9
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Press release
![Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL](https://static.wixstatic.com/media/52c921_a60aea0e358f405888e118d3bd00848c~mv2.png/v1/fill/w_95,h_111,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_a60aea0e358f405888e118d3bd00848c~mv2.png)
Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL
Schmidl C*, Vladimer GI*, Rendeiro AF*, Schnabl S*, Krausgruber T, Taubert C, Krall N, Pemovska T, Araghi M, Snijder B, Hubmann R, Ringler A, Runggatscher K, Demirtas D, de la Fuente OL, Hilgarth M, Skrabs C, Porpaczy E, Gruber M, Hoermann G, Kubicek S, Staber PB, Shehata M*, Superti-Furga G*, Jäger U*, Bock C*
Nature Chemical Biology  15, 232-240 (2019). DOI: 10.1038/s41589-018-0205-2
Donwload PDF
![Open access logo](https://static.wixstatic.com/media/52c921_87f94e7a576e45e6a642ae78dc3c88f6~mv2.png/v1/fill/w_97,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/open_access.png)
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
Read online (without subscription)
![The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space](https://static.wixstatic.com/media/52c921_b6c92a9d882f4671b097a8980df01c8c~mv2.png/v1/fill/w_129,h_111,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_b6c92a9d882f4671b097a8980df01c8c~mv2.png)
The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space
Klughammer J*, Kiesel B*, Roetzer T, Fortelny N, Nemc A, Nenning KH, Furtner J, Sheffield NC, Datlinger P, Peter N, Nowosielski M, Augustin M, Mischkulnig M, Strobel T, Alpar D, Ergüner B, Senekowitsch M, Moser P, Freyschlag CF, Kerschbaumer J, Thomé C, Grams AE, Stockhammer G, Kitzwoegerer M, Oberndorfer S, Marhold F, Weis S, Trenkler J, Buchroithner J, Pichler J, Haybaeck J, Krassnig S, Mahdy Ali K, von Campe G, Payer F, Sherif C, Preiser J, Hauser T, Winkler PA, Kleindienst W, Wurtz F, Brandner-Kokalj T, Stultschnig M, Schweiger S, Dieckmann K, Preusser M, Langs G, Baumann B, Knosp E, Widhalm G, Marosi C, Hainfellner JA, Woehrer A*, Bock C*
Nature Medicine  24, 1611-1624 (2018). DOI: 10.1038/s41591-018-0156-x
Donwload PDF
![Open access logo](https://static.wixstatic.com/media/52c921_87f94e7a576e45e6a642ae78dc3c88f6~mv2.png/v1/fill/w_97,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/open_access.png)
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
Read online (without subscription)
![VCF.Filter: interactive prioritization of disease-linked genetic variants from sequencing data](https://static.wixstatic.com/media/52c921_fb15395ab8724dbbaf805929eb4a2daa~mv2.png/v1/fill/w_60,h_111,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_fb15395ab8724dbbaf805929eb4a2daa~mv2.png)
VCF.Filter: interactive prioritization of disease-linked genetic variants from sequencing data
Müller H, Jimenez-Heredia R, Krolo A, Hirschmugl T, Dmytrus J, Boztug K, Bock C
Nucleic Acids Research  45, W567-W572 (2017). DOI: 10.1093/nar/gkx425
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Press release
![Pooled CRISPR screening with single-cell transcriptome readout](https://static.wixstatic.com/media/52c921_be61506eff884da9869505b7235999e7~mv2.png/v1/fill/w_174,h_111,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_be61506eff884da9869505b7235999e7~mv2.png)
Pooled CRISPR screening with single-cell transcriptome readout
Datlinger P, Schmidl C, Rendeiro A, Krausgruber T, Traxler P, Klughammer J, Schuster L, Kuchler A, Alpar D, Bock C
Nature Methods  14, 297-301 (2017). DOI: 10.1038/nmeth.4177
Donwload PDF
![Open access logo](https://static.wixstatic.com/media/52c921_87f94e7a576e45e6a642ae78dc3c88f6~mv2.png/v1/fill/w_97,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/open_access.png)
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
Read online (without subscription)
![DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma](https://static.wixstatic.com/media/52c921_337d6ed2e2be464a900b4ea6d7ad50de~mv2.png/v1/fill/w_69,h_111,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_337d6ed2e2be464a900b4ea6d7ad50de~mv2.png)
DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma
Sheffield NC, Pierron G, Klughammer J, Datlinger P, Schönegger A, Schuster M, Hadler J, Surdez D, Guillemot D, Lapouble E, Freneaux P, Champigneulle J, Bouvier R, Walder D, Ambros IM, Hutter C, Sorz E, Amaral AT, de Alava E, Schallmoser K, Strunk D, Rinner B, Liegl-Atzwanger B, Huppertz B, Leithner A, de Pinieux G, Terrier P, Laurence V, Michon J, Ladenstein R, Holter W, Windhager R, Dirksen U, Ambros PF, Delattre O, Kovar H, Bock C*, Tomazou EM*
Nature Medicine  23, 386-395 (2017). DOI: 10.1038/nm.4273
Donwload PDF
![Open access logo](https://static.wixstatic.com/media/52c921_87f94e7a576e45e6a642ae78dc3c88f6~mv2.png/v1/fill/w_97,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/open_access.png)
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
Read online (without subscription)
![DNA methylation dynamics of human hematopoietic stem cell differentiation](https://static.wixstatic.com/media/52c921_dc9b24d6bafa4f1892b82edbfb5c2ab6~mv2.jpg/v1/fill/w_178,h_111,al_c,q_80,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_dc9b24d6bafa4f1892b82edbfb5c2ab6~mv2.jpg)
DNA methylation dynamics of human hematopoietic stem cell differentiation
Farlik M*, Halbritter F*, Müller F*, Choudry FA, Ebert P, Klughammer J, Farrow S, Santoro A, Ciaurro V, Mathur A, Uppal R, Stunnenberg HG, Ouwehand WH, Laurenti E, Lengauer T, Frontini M*, Bock C*
Cell Stem Cell  19, 808-822 (2016). DOI: 10.1016/j.stem.2016.10.019
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
![Preserve personal freedom in networked societies](https://static.wixstatic.com/media/52c921_fdcde9c7e2524e48b6b09b08e5360ce7~mv2.png/v1/fill/w_108,h_111,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_fdcde9c7e2524e48b6b09b08e5360ce7~mv2.png)
Preserve personal freedom in networked societies
Bock C
Nature  537, 9 (2016). DOI: 10.1038/537009a
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Project website
Press release
![Specification of tissue-resident macrophages during organogenesis](https://static.wixstatic.com/media/52c921_963391aafaf9472991998d658a6fe2c6~mv2.jpg/v1/fill/w_162,h_111,al_c,q_80,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_963391aafaf9472991998d658a6fe2c6~mv2.jpg)
Specification of tissue-resident macrophages during organogenesis
Mass E*, Ballesteros I*, Farlik M*, Halbritter F*, Günther P, Crozet L, Jacome-Galarza CE, Händler K, Klughammer J, Kobayashi Y, Gomez-Perdiguero E, Schultze JL, Beyer M*, Bock C*, Geissmann F*
Science  353, 6304 (2016). DOI: 10.1126/science.aaf4238
Donwload PDF
![Open access logo](https://static.wixstatic.com/media/52c921_87f94e7a576e45e6a642ae78dc3c88f6~mv2.png/v1/fill/w_97,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/open_access.png)
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
Read online (without subscription)
![Chromatin accessibility maps of chronic lymphocytic leukaemia identify subtype-specific epigenome signatures and transcription regulatory networks](https://static.wixstatic.com/media/52c921_3efbd2350dfb45c9b9610be736adec07~mv2.png/v1/fill/w_159,h_111,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_3efbd2350dfb45c9b9610be736adec07~mv2.png)
Chromatin accessibility maps of chronic lymphocytic leukaemia identify subtype-specific epigenome signatures and transcription regulatory networks
Rendeiro AF*, Schmidl C*, Strefford JC*, Walewska R, Davis Z, Farlik M, Oscier D, Bock C*
Nature Communications  7, 11938 (2016). DOI: 10.1038/ncomms11938
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
![Quantitative comparison of DNA methylation assays for large-scale validation and epigenetic biomarker development](https://static.wixstatic.com/media/52c921_afb378c136d14d579718b77a40eeba29~mv2.png/v1/fill/w_126,h_111,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_afb378c136d14d579718b77a40eeba29~mv2.png)
Quantitative comparison of DNA methylation assays for large-scale validation and epigenetic biomarker development
Bock C, Halbritter F, Carmona FJ, Tierling S, Datlinger P, Assenov Y, Berdasco M, Bergmann AK, Booher K, Busato F, Campan M, Dahl C, Dahmcke CM, Diep D, Fernández AF, Gerhauser C, Haake A, Heilmann K, Holcomb T, Hussmann D, Ito M, Kreutz M, Kulis M, Lopez V, Nair SS, Paul DS, Plongthongkum N, Qu W, Queirós AC, Sauter G, Schlomm T, Stirzaker C, Statham A, Strogantsev R, Urdinguio RG, Walter K, Weichenhan D, Weisenberger DJ, Beck S, Clark SJ, Esteller M, Ferguson-Smith AC, Fraga MF, Guldberg P, Hansen LL, Laird PW, Martin-Subero JI, Nygren AOH, Peist R, Plass C, Shames DS, Siebert R, Sun X, Tost J, Walter J, Zhang K, for the BLUEPRINT consortium
Nature Biotechnology  34, 726-737 (2016). DOI: 10.1038/nbt.3605
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
![Multi-omics of single cells: Strategies and applications](https://static.wixstatic.com/media/52c921_3b37e7cc787c470bb527d16b4e4d297e~mv2.jpg/v1/fill/w_164,h_111,al_c,q_80,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_3b37e7cc787c470bb527d16b4e4d297e~mv2.jpg)
Multi-omics of single cells: Strategies and applications
Bock C, Farlik M, Sheffield NC
Trends in Biotechnology  34, 605-608 (2016). DOI: 10.1016/j.tibtech.2016.04.004
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Project website
Press release
![Single-cell transcriptomes reveal characteristic features of human pancreatic islet cell types](https://static.wixstatic.com/media/52c921_7f552f523bfa429bb56fbf72f3bd282b~mv2.jpg/v1/fill/w_155,h_111,al_c,q_80,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_7f552f523bfa429bb56fbf72f3bd282b~mv2.jpg)
Single-cell transcriptomes reveal characteristic features of human pancreatic islet cell types
Li J*, Klughammer J*, Farlik M*, Penz T*, Spittler A, Barbieux C, Berishvili E, Bock C*, Kubicek S*
EMBO Reports  17, 178-187 (2016). DOI: 10.15252/embr.201540946
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
![LOLA: Enrichment analysis for genomic region sets and regulatory elements in R and Bioconductor](https://static.wixstatic.com/media/52c921_1ab1893cfd924dc089c385fb0283bebb~mv2.png/v1/fill/w_185,h_45,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_1ab1893cfd924dc089c385fb0283bebb~mv2.png)
LOLA: Enrichment analysis for genomic region sets and regulatory elements in R and Bioconductor
Sheffield NC, Bock C
Bioinformatics  32, 587-589 (2016). DOI: 10.1093/bioinformatics/btv612
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Press release
![Differential DNA methylation analysis without a reference genome](https://static.wixstatic.com/media/52c921_b9de78f2a78e459d8e2b21aec479ac30~mv2.jpg/v1/fill/w_111,h_111,al_c,q_80,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_b9de78f2a78e459d8e2b21aec479ac30~mv2.jpg)
Differential DNA methylation analysis without a reference genome
Klughammer J, Datlinger P, Printz D, Sheffield NC, Farlik M, Hadler J, Fritsch G, Bock C
Cell Reports  13, 2621-2633 (2015). DOI: 10.1016/j.celrep.2015.11.024
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Press release
![altmetric.png](https://static.wixstatic.com/media/52c921_9df8b9fb18674f7b95b0a1decc437bd4~mv2.png/v1/fill/w_38,h_37,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/altmetric.png)
![ChIPmentation: fast, robust, low-input ChIP-seq for histones and transcription factors](https://static.wixstatic.com/media/52c921_b08a8bef39044e49978080426744238c~mv2.png/v1/fill/w_128,h_111,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_b08a8bef39044e49978080426744238c~mv2.png)
ChIPmentation: fast, robust, low-input ChIP-seq for histones and transcription factors
Schmidl C*, Rendeiro AF*, Sheffield NC, Bock C
Nature Methods  12, 963-965 (2015). DOI: 10.1038/nmeth.3542
Donwload PDF
![Open access logo](https://static.wixstatic.com/media/52c921_87f94e7a576e45e6a642ae78dc3c88f6~mv2.png/v1/fill/w_97,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/open_access.png)
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
Read online (without subscription)
![Single-cell DNA methylome sequencing and bioinformatic inference of epigenomic cell-state dynamics](https://static.wixstatic.com/media/52c921_826127fd3fb441d4b22ae8c446bd47f6~mv2.jpg/v1/fill/w_111,h_111,al_c,q_80,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_826127fd3fb441d4b22ae8c446bd47f6~mv2.jpg)
Single-cell DNA methylome sequencing and bioinformatic inference of epigenomic cell-state dynamics
Farlik M*, Sheffield NC*, Nuzzo A, Datlinger P, Schönegger A, Klughammer J, Bock C
Cell Reports  10, 1386-1397 (2015). DOI: 10.1016/j.celrep.2015.02.001
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
![Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1](https://static.wixstatic.com/media/52c921_f2d1a78c915047049265e51be23554f9~mv2.jpg/v1/fill/w_111,h_111,al_c,q_80,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_f2d1a78c915047049265e51be23554f9~mv2.jpg)
Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1
Tomazou EM*, Sheffield NC*, Schmidl C, Schuster M, Schönegger A, Datlinger P, Kubicek S, Bock C*, Kovar H*
Cell Reports  10, 1082-1095 (2015). DOI: 10.1016/j.celrep.2015.01.042
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
![Comprehensive analysis of DNA methylation data with RnBeads](https://static.wixstatic.com/media/52c921_3cd0ca44115c45258e6d409233933428~mv2.png/v1/fill/w_185,h_71,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_3cd0ca44115c45258e6d409233933428~mv2.png)
Comprehensive analysis of DNA methylation data with RnBeads
Assenov Y*, Müller F*, Lutsik P*, Walter J, Lengauer T, Bock C
Nature Methods  11, 1138-1140 (2014). DOI: 10.1038/nmeth.3115
Donwload PDF
![Open access logo](https://static.wixstatic.com/media/52c921_87f94e7a576e45e6a642ae78dc3c88f6~mv2.png/v1/fill/w_97,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/open_access.png)
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
Read online (without subscription)
Press release
![altmetric.png](https://static.wixstatic.com/media/52c921_9df8b9fb18674f7b95b0a1decc437bd4~mv2.png/v1/fill/w_38,h_37,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/altmetric.png)
![Recommendations for the design and analysis of epigenome-wide association studies](https://static.wixstatic.com/media/52c921_dc90f244f95b4bcab6a612d5a1c9ddd1~mv2.jpg/v1/fill/w_111,h_111,al_c,q_80,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_dc90f244f95b4bcab6a612d5a1c9ddd1~mv2.jpg)
Recommendations for the design and analysis of epigenome-wide association studies
Michels KB, Binder AM, Dedeurwaerder S, Epstein CB, Greally JM, Gut I, Houseman EA, Izzi B, Kelsey KT, Meissner A, Milosavljevic A, Siegmund KD, Bock C*, Irizarry RA*
Nature Methods  10, 949-955 (2013). DOI: 10.1038/nmeth.2632
![Open access logo](https://static.wixstatic.com/media/52c921_87f94e7a576e45e6a642ae78dc3c88f6~mv2.png/v1/fill/w_97,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/open_access.png)
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Project website
Press release
![Analysing and interpreting DNA methylation data](https://static.wixstatic.com/media/52c921_eeaee424cd004b69a6f0b174b3bd5f9f~mv2.png/v1/fill/w_185,h_103,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_eeaee424cd004b69a6f0b174b3bd5f9f~mv2.png)
Analysing and interpreting DNA methylation data
Bock C
Nature Reviews Genetics  13, 705-719 (2012). DOI: 10.1038/nrg3273
![Open access logo](https://static.wixstatic.com/media/52c921_87f94e7a576e45e6a642ae78dc3c88f6~mv2.png/v1/fill/w_97,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/open_access.png)
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Project website
Press release
![Managing drug resistance in cancer: Lessons from HIV therapy](https://static.wixstatic.com/media/52c921_2ea3f560028d4dadb49ebc7deda040ba~mv2.png/v1/fill/w_136,h_111,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_2ea3f560028d4dadb49ebc7deda040ba~mv2.png)
Managing drug resistance in cancer: Lessons from HIV therapy
Bock C, Lengauer T
Nature Reviews Cancer  12, 494-501 (2012). DOI: 10.1038/nrc3297
![Open access logo](https://static.wixstatic.com/media/52c921_87f94e7a576e45e6a642ae78dc3c88f6~mv2.png/v1/fill/w_97,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/open_access.png)
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_127,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Project website
Press release
Main publications from Christoph Bock’s postdoctoral research (Broad Institute & Harvard University) and PhD studies (Max Planck Institute for Informatics)
![EpiExplorer: live exploration and global analysis of large epigenomic datasets](https://static.wixstatic.com/media/52c921_565acd470ba247768dfe6ca37ef4d0ec~mv2.png/v1/fill/w_185,h_46,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_565acd470ba247768dfe6ca37ef4d0ec~mv2.png)
EpiExplorer: live exploration and global analysis of large epigenomic datasets
Halachev K, Bast H, Albrecht F, Lengauer T, Bock C
Genome Biology  13, R96 (2012). DOI: 10.1186/gb-2012-13-10-r96
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_29,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_112,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Press release
![DNA methylation dynamics during in vivo differentiation of blood and skin stem cells](https://static.wixstatic.com/media/52c921_48e72bde335d43d89f858bc8c0a92550~mv2.jpg/v1/fill/w_185,h_55,al_c,q_80,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_48e72bde335d43d89f858bc8c0a92550~mv2.jpg)
DNA methylation dynamics during in vivo differentiation of blood and skin stem cells
Bock C, Beerman I, Lien WH, Smith Z, Gu H, Boyle P, Gnirke A, Fuchs E, Rossi DJ, Meissner A
Molecular Cell  47, 633-47 (2012). DOI: 10.1016/j.molcel.2012.06.019
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_29,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_112,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Press release
![BiQ Analyzer HT: locus-specific analysis of DNA methylation by high-throughput bisulfite sequencing](https://static.wixstatic.com/media/52c921_e34c14ce5bf94e9494aa32d58423b150~mv2.jpg/v1/fill/w_185,h_51,al_c,q_80,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_e34c14ce5bf94e9494aa32d58423b150~mv2.jpg)
BiQ Analyzer HT: locus-specific analysis of DNA methylation by high-throughput bisulfite sequencing
Lutsik, P, Feuerbach, L, Arand, J, Lengauer, T, Walter, J & Bock, C
Nucleic Acids Research  39, W551-W556 (2011). DOI: 10.1093/nar/gkr312
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_29,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_112,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Press release
![RRBSMAP: A fast, accurate and user-friendly alignment tool for reduced representation bisulfite sequencing](https://static.wixstatic.com/media/52c921_3c73d664bbfa45d0b9c5ce37e244708c~mv2.png/v1/fill/w_113,h_111,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_3c73d664bbfa45d0b9c5ce37e244708c~mv2.png)
RRBSMAP: A fast, accurate and user-friendly alignment tool for reduced representation bisulfite sequencing
Xi Y*, Bock C*, Müller F, Sun D, Meissner A, Li W
Bioinformatics  28, 430-432 (2011). DOI: 10.1093/bioinformatics/btr668
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_29,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_112,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Press release
![Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines](https://static.wixstatic.com/media/52c921_dea43ae8c88e4f0a99b8a8ada25651e7~mv2.jpg/v1/fill/w_111,h_111,al_c,q_80,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_dea43ae8c88e4f0a99b8a8ada25651e7~mv2.jpg)
Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines
Bock C*, Kiskinis E*, Verstappen G*, Gu H, Boulting G, Smith ZD, Ziller M, Croft GF, Amoroso MW, Oakley DH, Gnirke A, Eggan K*, Meissner A*
Cell  144, 439-452 (2011). DOI: 10.1016/j.cell.2010.12.032
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_29,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_112,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Press release
![Quantitative comparison of genome-wide DNA methylation mapping technologies](https://static.wixstatic.com/media/52c921_287037223e854e89840b0fe29d7f609c~mv2.jpg/v1/fill/w_170,h_111,al_c,q_80,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_287037223e854e89840b0fe29d7f609c~mv2.jpg)
Quantitative comparison of genome-wide DNA methylation mapping technologies
Bock C*, Tomazou EM*, Brinkman AB, Müller F, Simmer F, Gu H, Jäger N, Gnirke A, Stunnenberg HG, Meissner A
Nature Biotechnology  28, 1106-1114 (2010). DOI: 10.1038/nbt.1681
Donwload PDF
![Open access logo](https://static.wixstatic.com/media/52c921_87f94e7a576e45e6a642ae78dc3c88f6~mv2.png/v1/fill/w_97,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/open_access.png)
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_29,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
Read online (without subscription)
Press release
![Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution](https://static.wixstatic.com/media/52c921_73d38bee1abe47e984787aa29dca6aa6~mv2.png/v1/fill/w_170,h_111,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_73d38bee1abe47e984787aa29dca6aa6~mv2.png)
Genome-scale DNA methylation mapping of clinical samples at single-nucleotide resolution
Gu H*, Bock C*, Mikkelsen TS, Jäger N, Smith ZD, Tomazou EM, Gnirke A, Lander ES, Meissner A
Nature Methods  7, 133-136 (2010). DOI: 10.1038/nmeth.1414
Donwload PDF
![Open access logo](https://static.wixstatic.com/media/52c921_87f94e7a576e45e6a642ae78dc3c88f6~mv2.png/v1/fill/w_97,h_30,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/open_access.png)
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_29,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
Read online (without subscription)
Press release
![Epigenetic biomarker development](https://static.wixstatic.com/media/52c921_c3d5ae6420004df6a2701bba317c0201~mv2.jpeg/v1/fill/w_185,h_108,al_c,q_80,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_c3d5ae6420004df6a2701bba317c0201~mv2.jpeg)
Epigenetic biomarker development
Bock C
Epigenomics  1, 99-110 (2009). DOI: 10.2217/epi.09.6
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_29,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_112,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Project website
Press release
![MethMarker: User-friendly design and optimization of gene-specific DNA methylation assays](https://static.wixstatic.com/media/52c921_baaa0e7431054a82af09fd41e3826e97~mv2.png/v1/fill/w_185,h_91,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_baaa0e7431054a82af09fd41e3826e97~mv2.png)
MethMarker: User-friendly design and optimization of gene-specific DNA methylation assays
Schüffler P, Mikeska T, Waha A, Lengauer T, Bock C
Genome Biology  10, R105 (2009). DOI: 10.1186/gb-2009-10-10-r105
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_29,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_112,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Press release
![altmetric.png](https://static.wixstatic.com/media/52c921_9df8b9fb18674f7b95b0a1decc437bd4~mv2.png/v1/fill/w_37,h_37,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/altmetric.png)
![EpiGRAPH: User-friendly software for statistical analysis and prediction of epigenomic data](https://static.wixstatic.com/media/52c921_0effe354fdbc4058863ef31e5872cabb~mv2.png/v1/fill/w_115,h_111,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_0effe354fdbc4058863ef31e5872cabb~mv2.png)
EpiGRAPH: User-friendly software for statistical analysis and prediction of epigenomic data
Bock C, Halachev K, Büch J, Lengauer T
Genome Biology  10, R14 (2009). DOI: 10.1186/gb-2009-10-2-r14
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_29,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_112,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Press release
![altmetric.png](https://static.wixstatic.com/media/52c921_9df8b9fb18674f7b95b0a1decc437bd4~mv2.png/v1/fill/w_37,h_37,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/altmetric.png)
![Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping](https://static.wixstatic.com/media/52c921_64150c07a7e04a1d86df4b633b5560fe~mv2.png/v1/fill/w_148,h_111,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_64150c07a7e04a1d86df4b633b5560fe~mv2.png)
Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping
Bock C, Walter J, Paulsen M, Lengauer T
Nucleic Acids Research  36, e55 (2008). DOI: 10.1093/nar/gkn122
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_29,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_112,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Project website
Press release
![altmetric.png](https://static.wixstatic.com/media/52c921_9df8b9fb18674f7b95b0a1decc437bd4~mv2.png/v1/fill/w_37,h_37,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/altmetric.png)
![Computational epigenetics](https://static.wixstatic.com/media/52c921_479dfb1d4ce84717aafd71585d5fa659~mv2.jpeg/v1/fill/w_185,h_104,al_c,q_80,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_479dfb1d4ce84717aafd71585d5fa659~mv2.jpeg)
Computational epigenetics
Bock C, Lengauer T
Bioinformatics  24, 01.Oct (2008). DOI: 10.1093/bioinformatics/btm546
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_29,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_112,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Project website
Press release
![altmetric.png](https://static.wixstatic.com/media/52c921_9df8b9fb18674f7b95b0a1decc437bd4~mv2.png/v1/fill/w_37,h_37,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/altmetric.png)
![CpG island mapping by epigenome prediction](https://static.wixstatic.com/media/52c921_22a2d550a23748b1968c7afee746556b~mv2.png/v1/fill/w_185,h_99,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_22a2d550a23748b1968c7afee746556b~mv2.png)
CpG island mapping by epigenome prediction
Bock C, Walter J, Paulsen M, Lengauer T
PLOS Computational Biology  3, e110 (2007). DOI: 10.1371/journal.pcbi.0030110
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_29,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_112,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Project website
Press release
![altmetric.png](https://static.wixstatic.com/media/52c921_9df8b9fb18674f7b95b0a1decc437bd4~mv2.png/v1/fill/w_37,h_37,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/altmetric.png)
![CpG island methylation in human lymphocytes is highly correlated with DNA sequence, repeats, and predicted DNA structure](https://static.wixstatic.com/media/52c921_e285ff403411472bbb497ba87f1e22c1~mv2.png/v1/fill/w_125,h_111,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/52c921_e285ff403411472bbb497ba87f1e22c1~mv2.png)
CpG island methylation in human lymphocytes is highly correlated with DNA sequence, repeats, and predicted DNA structure
Bock C, Paulsen M, Tierling S, Mikeska T, Lengauer T, Walter J
PLOS Genetics  2, e26 (2006). DOI: 10.1371/journal.pgen.0020026
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_29,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_112,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Project website
Press release
![altmetric.png](https://static.wixstatic.com/media/52c921_9df8b9fb18674f7b95b0a1decc437bd4~mv2.png/v1/fill/w_37,h_37,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/altmetric.png)
![BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing](https://static.wixstatic.com/media/52c921_6c3736a113d341759eb28a256d19c45f~mv2.png/v1/fill/w_185,h_111,al_c,lg_1,q_85,enc_avif,quality_auto/52c921_6c3736a113d341759eb28a256d19c45f~mv2.png)
BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing
Bock C, Reither S, Mikeska T, Paulsen M, Walter J, Lengauer T
Bioinformatics  21, 4067-4068 (2005). DOI: 10.1093/bioinformatics/bti652
Donwload PDF
![bioarchive-logo-small.png](https://static.wixstatic.com/media/52c921_a0c940a954324ffe95420b62f30074b4~mv2.png/v1/fill/w_72,h_29,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/bioarchive-logo-small.png)
![epmc-logo-small.png](https://static.wixstatic.com/media/52c921_047688f3762b4f0c92d90c993f12e7bb~mv2.png/v1/fill/w_112,h_35,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/epmc-logo-small.png)
Read online (without subscription)
Project website
Press release
![altmetric.png](https://static.wixstatic.com/media/52c921_9df8b9fb18674f7b95b0a1decc437bd4~mv2.png/v1/fill/w_37,h_37,al_c,q_85,usm_0.66_1.00_0.01,enc_avif,quality_auto/altmetric.png)