We use multi-omics profiling and CRISPR technology to discover exciting new biology in cancer and immunity, and we take the most interesting results forward, together with our clinical partners to make them useful for precision medicine.
Important biological discoveries are often enabled by groundbreaking new technologies. We are strongly committed to technology development, especially in the areas of epigenome profiling, single-cell sequencing, genome/epigenome editing, and synthetic biology.
We develop and apply machine learning (ML) and artificial intelligence (AI) methods for the analysis of large biomedical datasets. For example, we work on interpretable deep learning to make machine learning more useful for biomedical research.
Human Cell Atlas & single-cell biology of organoids
Single-cell sequencing and spatial profiling technologies uncover the molecular complexity that is inherent in human organs. We contribute to the Human Cell Atlas on its quest to map all human cell types, with a focus on human organoids as experimentally tractable models of development, disease, and therapy.
Immune cell engineering and synthetic cell biology
CAR T cells have shown dramatic efficacy for blood cancers and may spearhead a broad shift toward personalized, cell-based therapies. We use high-throughput CRISPR screening and single-cell sequencing technology to design synthetic immune cells.